Complete Curriculum Vitae

EDUCATION

1991 University of Cincinnati, Cincinnati, Ohio, B.S. Biology

1999 Miami University, Oxford, Ohio, Ph.D. Microbiology
Dissertation title: Molecular and Genetic Analysis of Potential Virulence Determinants in the Brazilian Purpuric Fever Clone of Haemophilus influenzae biogroup aegyptius

RESEARCH INTERESTS

Application of classical genetics and post-genomic methods to characterize bacterial pathogenicity, virulence gene regulation, global regulatory networks, and host-pathogen interactions

CURRENT PROJECTS

Phylochip Project

Oral Cavity Diagnostics

SELECTED PUBLICATIONS

Graber, K. R., L. M. Smoot, L. A. Actis. 1998. Expression of iron binding and hemin binding activity in the dental pathogen Actinobacillus actinomycetemcomitans. FEMS Microbiol. Lett. 163:135-142.

Smoot, L. M., E. C. Bell, K. A. Corbin, R. L. Paz, J. N. Steenbergen, A. C. Harner, and L. A. Actis. 1998. Molecular and genetic analysis of iron uptake proteins in the Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius. Front. Biosci. 3:989-996.

Smoot, L. M., E. C. Bell, J. H. Crosa, and L. A. Actis. 1999. Fur and iron transport proteins in the Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius. J. Med. Micro. 48:1-8.

Graham, M. R., L. M. Smoot, B. Lei, and J. M. Musser. 2001. Toward a genome-scale understanding of group A Streptococcus pathogenesis. Curr. Opin. Microbiol. 4:65-70.

Reid, S. R., N. P. Hoe, L. M. Smoot, and J. M. Musser. 2001. Group A Streptococcus: allelic variation, population genetics, and host-pathogen interactions. J. Clin. Invest. 107:393-399.

Smoot, L. M., J. C. Smoot, M. R. Graham, G. A. Somerville, D. E. Sturdevant, C. A. Lux Migliaccio, G. L. Sylva, and J. M. Musser. 2001. Global differential gene expression in response to growth temperature alteration in group A Streptococcus. Proc. Natl. Acad. Sci. U.S.A. 98:10416-10421.

Chaussee, M. S., G. L. Sylva, D. E. Sturdevant, L. M. Smoot, M. R. Graham, R. O. Watson, and J. M. Musser. 2002. Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes. Infect. Immun. 70:762-770.

Smoot, J. C., K. D. Barbian, J. J. Van Gompel, L. M. Smoot, M. S. Chaussee, G. L. Sylva, D. E. Sturdevant, S. M. Mackie, L. D. Parkins, S. F. Porcella, S. B. Beres, D. S. Campbell, T. M. Smith, Q. Zhang, V. Kapur, J. A. Daly, L. G. Veasy, J. M. Musser. 2002. Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks. Proc. Natl. Acad. Sci. U.S.A. 99: 4668-4673.

Smoot, L. M., D. D. Hall, G. McGillivary, and L. A. Actis. 2002. Genomic analysis of the Brazilian purpuric fever clone of Haemophilus influenzae biogroup aegyptius using PCR-based subtractive hybridization. Infect. Immun. 70:2694-2699.

Lei, B., L. M. Smoot, H. Menning, J. M. Voyich, S. V. Kala, F. R. DeLeo, S. D. Reid, and J. M. Musser. 2002. Identification and characterization of a novel heme-binding cell-surface protein made by Streptococcus pyogenes. Infect. Immun. 70:4494-4500.

Graham, M. R., L. M. Smoot, C. A. Lux Migliaccio, K. Virtaneva, D. E. Sturdevant, S. F. Porcella, M. J. Federle, G. J. Adams, J. R. Scott, and J. M. Musser. 2002. Virulence control in group A Streptococcus by a two-component gene regulatory system: Global expression profiling and in vivo infection modeling. Proc. Natl. Acad. Sci. U.S.A. 99:13855-13860.