D-097. IL-8 Serum Levels in Patients with Helicobacter pylori Infection and Relation between Serological Markers

N. Kasifoglu, Y. Akgun, T. Saricam, A. Kiremitci, T. Us;
Eskişehir Osmangazi Univ., Eskisehir, TURKEY.

Background: In this study we aimed to investigate IL-8 serum levels in dyspeptic patients with Helicobacter pylori (H.pylori) infection and in control group. Methods: Our study group consisted of 172 patients with dyspepsia who underwent endoscopy. On the day of taking gastric tissues, serum samples were taken. H.pylori was investigated from tissues by Gram staining, urease test and culture method. From serum samples anti-CagA IgA, anti-CagA IgG, anti-Helicobacter pylori IgM, anti-Helicobacter pylori IgA, anti-Helicobacter pylori IgG and IL-8 levels were studied by EIA. These 172 patients had positive invasive and/or serological test results. For the control group, 20 patients with negative H.pylori invasive and serological test results were included. Results: Among 172 patients, 101 (58.7%) had normal IL-8 levels and 71 (41.3%) had high IL-8 levels. In 8 (40%) of 20 control patients IL-8 was high. The mean values of IL-8 were as 44.66 pg/ml and 42.03 pg/ml in positive and negative groups, respectively. The comparison of IL-8 serum levels and serological markers of patient and control groups is given in the table. Conclusion: Our observations implicate that there was no significant differences between H.pylori positive and negative patients with respect to IL-8 serum concentrations.

Table I. Comparison of anti-CagA and anti-H. pylori antibodies with IL-8 levels


IL-8 normal

IL-8 high

Anti-CagA IgA(-) IgG(-)
Anti-CagA IgA(-) IgG(+) Anti-CagA IgA(+) IgG(+)

46 (%59.0)
29 (%61.7) 26 (%55.3)

32 (%41.0)
18 (%38.3) 21 (%44.7)

Anti-HP IgG(-) IgM(-) IgA(-)
Anti-HP IgG(+) IgM(-) IgA(-) Anti-HP IgG(+) IgM and/or IgA(+)

6 (%46.2)
30 (%56.6) 65 (%61.3)

7 (%53.8)
23 (%43.4) 41 (%38.7)

Control group n:20

12 (%60.0)

8 (%40.0)