C-185. Kluyvera Infections in the Pediatric Population: Characteristics of an Emerging Pathogen

K. N. Mizell, J. A. Laurini, J. E. Carter;
Univ. of South Alabama, Mobile, AL.

Background: Originally characterized as a clinically insignificant commensal organism, the Gram-negative bacillus Kluyvera has emerged as the etiologic agent of clinically significant disease ranging from soft tissue infections to sepsis with multiorgan failure.Methods: A 9-year review of the medical database of a three hospital, 800-bed healthcare institution was performed to identify characteristics and treatment options of clinically significant cases of Kluyvera infection in the pediatric population. In addition, all previously reported cases of pediatric Kluyvera infection in the medical literature were reviewed.Results: Four clinically significant pediatric Kluyvera infections were identified in our medical database in addition to 11 reports in the medical literature. Analysis of the cases showed Kluyvera as a cause of urinary tract infection, bacteremia/sepsis, peritonitis, soft tissue infection, and meningitis in the pediatric population. Successful treatment options included the use of third-generation cephalosporins, tetracycline, aminoglycosides and fluoroquinolones but antimicrobial resistance was seen to first- and second-generation cephalosporins.Conclusions: For prompt and effective antimicrobial treatment, clinicians should be aware of the spectrum of disease and increasing clinical importance associated with this emerging and potentially deadly pathogen in the pediatric population.